TY - CHAP M1 - Book, Section TI - Oxidation of Fatty Acids: Ketogenesis A1 - Botham, Kathleen M. A1 - Mayes, Peter A. A2 - Rodwell, Victor W. A2 - Bender, David A. A2 - Botham, Kathleen M. A2 - Kennelly, Peter J. A2 - Weil, P. Anthony PY - 2018 T2 - Harper's Illustrated Biochemistry, 31e AB - OBJECTIVESAfter studying this chapter, you should be able to:Describe the processes by which fatty acids are transported in the blood, activated and transported into the matrix of the mitochondria for breakdown to obtain energy.Outline the β-oxidation pathway by which fatty acids are metabolized to acetyl-CoA and explain how this leads to the production of large quantities of ATP.Identify the three compounds termed “ketone bodies” and describe the reactions by which they are formed in liver mitochondria.Recognize that ketone bodies are important fuels for extrahepatic tissues and indicate the conditions in which their synthesis and use are favored.Indicate the three stages in the metabolism of fatty acids where ketogenesis is regulated.Indicate that overproduction of ketone bodies leads to ketosis and, if prolonged, ketoacidosis, and identify pathologic conditions when this occurs.Give examples of diseases associated with impaired fatty acid oxidation. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1160192486 ER -