TY  - CHAP
M1  - Book, Section
TI  - Mechanisms of Allergic Responses
A1  - Cahill, Katherine N.
A1  - Boyce, Joshua A.
A2  - Jameson, J. Larry
A2  - Fauci, Anthony S.
A2  - Kasper, Dennis L.
A2  - Hauser, Stephen L.
A2  - Longo, Dan L.
A2  - Loscalzo, Joseph
PY  - 2018
T2  - Harrison's Principles of Internal Medicine, 20e
AB  - The  term  atopy  implies  a  tendency  to  manifest  asthma,  rhinitis,  urticaria,  and  atopic  dermatitis  alone  or  in  combination,  in  association  with  the  presence  of  allergen-specific  IgE.  However,  individuals  without  an  atopic  background  may  also  develop  hypersensitivity  reactions,  particularly  urticaria  and  anaphylaxis,  associated  with  the  presence  of  IgE.  Since  mast  cells  are  key  effector  cells  in  allergic  rhinitis  and  asthma,  and  the  dominant  effector  in  urticaria,  anaphylaxis,  and  systemic  mastocytosis,  its  developmental  biology,  activation  pathway,  product  profile,  and  target  tissues  will  be  considered  in  the  introduction  to  these  clinical  disorders.  Dysregulation  of  mast  cell  development  seen  in  mastocytosis  will  be  covered  in  a  separate  chapter.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1177736703
ER  -