TY - CHAP M1 - Book, Section TI - Immunoglobulin A Nephropathy and Henoch–Schönlein Purpura A1 - Madan, Niti A1 - Hwang, Vicki J. A1 - Yeun, Jane Y. A1 - Weiss, Robert H. A2 - Lerma, Edgar V. A2 - Rosner, Mitchell H. A2 - Perazella, Mark A. PY - 2017 T2 - CURRENT Diagnosis & Treatment: Nephrology & Hypertension, 2e AB - ESSENTIALS OF DIAGNOSISIgA nephropathy is the most common form of glomerular disease in the world.IgA nephropathy is characterized by frequent bouts of microscopic and/or macroscopic hematuria, often following an upper respiratory infection (URI).The pathophysiology of IgA nephropathy is related to aberrant glycosylation of the IgA molecule.The pathogenesis of IgA nephropathy is considered to involve a “multi-hit” model.The diagnosis is established by kidney biopsy showing prominent globular deposits of IgA often accompanied by C3 and IgG in the mesangium.There is no specific treatment of IgA nephropathy and 10–20% of patients with the disease will progress to end-stage kidney disease within 10 years of diagnosis, and 25–40% within 20 years. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1149114016 ER -