TY  - CHAP
M1  - Book, Section
TI  - Focal Segmental Glomerulosclerosis
A1  - Trachtman, Howard
A1  - Gipson, Debbie S.
A2  - Lerma, Edgar V.
A2  - Rosner, Mitchell H.
A2  - Perazella, Mark A.
PY  - 2017
T2  - CURRENT Diagnosis & Treatment: Nephrology & Hypertension, 2e
AB  - ESSENTIALS  OF  DIAGNOSISFocal  segmental  glomerulosclerosis  (FSGS)  can  be  primary  or  secondary.Diagnosis  requires  the  presence  of  the  characteristic  histopathologic  lesion.Genetic  abnormalities  in  podocyte  proteins  may  account  for  25%  of  primary  FSGS  in  high-risk  populations.The  presenting  complaint  is  usually  proteinuria  or  nephrotic  syndrome.Nearly  50%  of  cases  progress  to  end-stage  renal  disease  (ESRD)  over  5–10  years  and  disease  recurs  in  up  to  20%  of  those  who  receive  a  kidney  transplant.Failure  to  respond  to  corticosteroid  treatment  is  a  poor  prognostic  sign  and  there  is  no  proven  therapy  in  these  patients.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/16
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1149113826
ER  -