TY - CHAP M1 - Book, Section TI - Tumor Lysis Syndrome A1 - Rastegar, Mandana A1 - Shirali, Anushree A2 - Lerma, Edgar V. A2 - Rosner, Mitchell H. A2 - Perazella, Mark A. PY - 2017 T2 - CURRENT Diagnosis & Treatment: Nephrology & Hypertension, 2e AB - Essentials of DiagnosisDue to tumor cell lysis (TLS), commonly in high-risk hematologic malignancies and/or tumors with large cellular burden.Results when intracellular contents of nucleic acids, potassium, phosphorus are rapidly released into the bloodstream.Characterized by laboratory findings of hyperuricemia, hyperkalemia, hyperphosphatemia, and/or hypocalcemia with clinical manifestations of renal, cardiac, and/or neurologic dysfunction.Knowledge of risk factors of TLS and early detection of TLS are imperative to implementing preventive and therapeutic strategies to reduce morbidity and mortality. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1149112562 ER -