TY - CHAP M1 - Book, Section TI - CARDIAC TRANSPLANTATION A1 - Kittleson, Michelle M. A1 - Patel, Jignesh K. A1 - Kobashigawa, Jon A. A2 - Fuster, Valentin A2 - Harrington, Robert A. A2 - Narula, Jagat A2 - Eapen, Zubin J. PY - 2017 T2 - Hurst's The Heart, 14e AB - Despite major advances in the treatment of end-stage heart disease, a sizable number of patients with refractory heart failure (HF), progressive angina, or uncontrolled ventricular arrhythmias cannot be stabilized with medical or interventional/surgical therapy and suffer significant morbidity and mortality.1 In these patients, biological replacement of the heart (cardiac transplantation) has become standard therapy and is widely accepted to improve quality and quantity of life in carefully selected patients. As technologic and engineering advances occur, support or replacement of the heart by mechanical devices (mechanical circulatory support [MCS]) offers additional options for patients with end-stage heart disease as a bridge to recovery, bridge to transplantation, or destination therapy. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/18 UR - accessmedicine.mhmedical.com/content.aspx?aid=1161716891 ER -