TY - CHAP M1 - Book, Section TI - MANAGEMENT OF MIXED VALVULAR HEART DISEASE A1 - Carabello, Blase A. A2 - Fuster, Valentin A2 - Harrington, Robert A. A2 - Narula, Jagat A2 - Eapen, Zubin J. PY - 2017 T2 - Hurst's The Heart, 14e AB - The 2006 American College of Cardiology (ACC)/American Heart Association (AHA) guidelines for the treatment of valvular heart disease (VHD) were notable for the paucity (0.3%) of the recommendations supported by a level of evidence A—that is, evidence supported by two or more randomized controlled trials (RCTs).1 Although several RCTs have been published since then and the evidence level supporting the 2014 guidelines improved markedly,2 there are no RCTs and indeed only limited data-driving management decisions in mixed VHD. In a 230-page document, the current guideline devotes scarcely two pages to the topic. The following chapter will summarize some of the modest data that are available. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/18 UR - accessmedicine.mhmedical.com/content.aspx?aid=1161731990 ER -