TY - CHAP M1 - Book, Section TI - Pain, Agitation, and Delirium in the Critical Care Setting A1 - Margolias, Gary A1 - Sterling, Michael A2 - McKean, Sylvia C. A2 - Ross, John J. A2 - Dressler, Daniel D. A2 - Scheurer, Danielle B. PY - 2017 T2 - Principles and Practice of Hospital Medicine, 2e AB - Key Clinical Questions What are the clinical and pharmacologic effects of single agent versus multiple agent sedative and analgesic administration? What is the best way to dose sedative, analgesic, and paralytic agents in the intensive care unit (ICU)? How do the pharmacokinetics and dosing of sedative, analgesic, and paralytic agents change with duration of infusion? What is the proper sequence to initiate sedatives, analgesics, and/or paralytics, and how does dosing refinement affect time to weaning and other predictors of favorable outcome? How do you select individual sedative, analgesic, or paralytic agents in critically ill patients? When do you decide to paralyze a ventilated patient? SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/25 UR - accessmedicine.mhmedical.com/content.aspx?aid=1137614471 ER -