TY - CHAP M1 - Book, Section TI - Smoke Exposure Models in COPD A1 - Geraghty, Patrick A1 - Foronjy, Robert A2 - Oropello, John M. A2 - Pastores, Stephen M. A2 - Kvetan, Vladimir PY - 1 T2 - Critical Care AB - KEY POINTSCOPD is a leading cause of death worldwide and the lack of effective therapies and continued smoking prevalence indicate that this will be a major public health challenge confronting physicians for years to come.COPD is a frequent cause of ICU admission and the diagnosis of COPD in ICU patients increases the risk of ICU delirium, ARDS, and in-hospital and postdischarge mortality.Our limited understanding of the pathogenesis of COPD has hindered advancements in treatment of this disease highlighting the need for more basic and clinical research.Animal models of COPD, particularly the cigarette smoke exposure model, reproduce key features of the disease providing the opportunity to gain key disease insights within a relatively short time frame.Findings from animal models have identified the importance of inflammation, proteases, oxidants, and apoptosis in the pathophysiology of this disease. Furthermore, these studies have established key injury repair mechanisms that are activated in the lung in COPD.The findings from these studies could lead to targeted strategies that block damaging injury responses and enhance protective lung repair responses in this disease. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1136417084 ER -