TY - CHAP M1 - Book, Section TI - Family History A1 - McCarthy, Jeanette J. A1 - Mendelsohn, Bryce A. PY - 2016 T2 - Precision Medicine: A Guide to Genomics in Clinical Practice AB - Family history is a risk factor for many common diseases, capturing both shared genetic variation and shared environment between family members. Because our understanding of genetic risk factors for common diseases is incomplete, family history remains an important component of any medical assessment. A family history of a common disease is usually associated with a two to threefold increased risk of disease in bloodline family relatives. To put this in context, this risk is much higher than for most known individual genetic variants for common diseases (average increased risk for variants discovered to date are about 1.18-fold). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1134734933 ER -