TY - CHAP M1 - Book, Section TI - The Human Genome and Genetic Variation A1 - McCarthy, Jeanette J. A1 - Mendelsohn, Bryce A. PY - 2016 T2 - Precision Medicine: A Guide to Genomics in Clinical Practice AB - The Human Genome Project has taught us a great deal about the different types of variations that exist in our genomes and their distribution across human populations. Humans are 99.9% identical at the DNA level, but the corollary is that at 0.1% of the nucleotide positions, translating to about 4–5 million basepairs on average, we differ[1]. These genetic differences will vary in their effect on human traits according to their location with respect to genes and their impact on the downstream proteins that those genes encode. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1134734583 ER -