TY - CHAP M1 - Book, Section TI - Adverse Drug Reactions A1 - Kasper, Dennis L. A1 - Fauci, Anthony S. A1 - Hauser, Stephen L. A1 - Longo, Dan L. A1 - Jameson, J. Larry A1 - Loscalzo, Joseph PY - 2016 T2 - Harrison's Manual of Medicine, 19e AB - Adverse drug reactions are among the most frequent problems encountered clinically and represent a common cause for hospitalization. They occur most frequently in pts receiving multiple drugs and are caused by: Errors in self-administration of prescribed drugs (quite common in the elderly);Exaggeration of intended pharmacologic effect (e.g., hypotension in a pt given antihypertensive drugs);Concomitant administration of drugs with synergistic effects (e.g., aspirin and warfarin);Cytotoxic reactions (e.g., hepatic necrosis due to acetaminophen);Immunologic mechanisms (e.g., quinidine-induced thrombocytopenia, hydralazine-induced SLE);Genetically determined enzymatic defects (e.g., primaquine-induced hemolytic anemia in G6PD deficiency); orIdiosyncratic reactions (e.g., chloramphenicol-induced aplastic anemia). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1128788740 ER -