TY - CHAP M1 - Book, Section TI - Targeted Therapy in Cancer A1 - Tsimberidou, Apostolia-Maria A2 - Kantarjian, Hagop M. A2 - Wolff, Robert A. PY - 2016 T2 - The MD Anderson Manual of Medical Oncology, 3e AB - The Human Genome Project has enabled sequencing of human DNA and led to advancements in technologies that detect genomic, transcriptional, proteomic, and epigenetic changes. These technologies, combined with novel drug development, have accelerated the implementation of personalized medicine. Personalized medicine uses concepts of the genetic and environmental bases of disease to individualize prevention, diagnosis, and treatment (1,2). Optimization of treatment using targeted therapy—molecules targeting specific enzymes, growth factor receptors, and signal transducers, thereby interfering with a variety of oncogenic cellular processes—and other strategies made possible by advances in translational medicine holds the promise of improving patient care (3). SN - PB - McGraw-Hill Medical CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1126745887 ER -