TY - CHAP M1 - Book, Section TI - Primary Biliary Cirrhosis A1 - Pratt, Daniel S. A2 - Greenberger, Norton J. A2 - Blumberg, Richard S. A2 - Burakoff, Robert PY - 2016 T2 - CURRENT Diagnosis & Treatment: Gastroenterology, Hepatology, & Endoscopy, 3e AB - ESSENTIALS OF DIAGNOSISMost patients with primary biliary cirrhosis (PBC) are asymptomatic at the time of diagnosis but eventually develop symptoms, including fatigue and pruritus.Consider PBC in any patient in whom liver enzymes are elevated in a cholestatic pattern; an isolated elevated alkaline phosphatase level always requires further evaluation.Antimitochondrial antibodies have 95% sensitivity for PBC and are central to the diagnosis. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/24 UR - accessmedicine.mhmedical.com/content.aspx?aid=1119991484 ER -