TY - CHAP M1 - Book, Section TI - Hematopoietic Agents: Growth Factors, Minerals, and Vitamins A1 - Kaushansky, Kenneth A1 - Kipps, Thomas J. A2 - Brunton, Laurence L. A2 - Chabner, Bruce A. A2 - Knollmann, Björn C. PY - 2015 T2 - Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 12e AB - The finite life span of most mature blood cells requires their continuous replacement, a process termed hematopoiesis. New cell production must respond to basal needs and states of increased demand. Red blood cell production can increase >20-fold in response to anemia or hypoxemia, white blood cell production increases dramatically in response to a systemic infection, and platelet production can increase 10- to 20-fold when platelet consumption results in thrombocytopenia. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2023/01/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1127868984 ER -