TY  - CHAP
M1  - Book, Section
TI  - 5-Hydroxytryptamine (Serotonin) and Dopamine
A1  - Sanders-Bush, Elaine
A1  - Hazelwood, Lisa
A2  - Brunton, Laurence L.
A2  - Chabner, Bruce A.
A2  - Knollmann, Björn C.
PY  - 2015
T2  - Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 12e
AB  - 5-Hydroxytryptamine  (5-HT,  serotonin)  and  dopamine  (DA)  are  neurotransmitters  in  the  central  nervous  system  (CNS)  and  also  have  prominent  peripheral  actions.  5-HT  is  found  in  high  concentrations  in  enterochromaffin  cells  throughout  the  GI  tract,  in  storage  granules  in  platelets,  and  broadly  throughout  the  CNS.  5-HT  regulates  smooth  muscle  in  the  cardiovascular  system  and  the  GI  tract  and  enhances  platelet  aggregation.  The  highest  concentrations  of  DA  are  found  in  the  brain;  dopamine  stores  are  also  present  peripherally  in  the  adrenal  medulla  and  the  transmitter  is  detectable  in  the  plexuses  of  the  GI  tract  and  in  enteric  nervous  system.  DA  modulates  peripheral  vascular  tone  to  modulate  renal  perfusion,  heart  rate,  and  vasoconstriction/dilation.  Fourteen  5-HT  receptor  subtypes  and  five  DA-receptor  subtypes  have  been  delineated  by  pharmacological  analyses  and  cDNA  cloning.  The  availability  of  cloned  receptors  has  allowed  the  development  of  subtype-selective  drugs  and  the  elucidation  of  actions  of  these  neurotransmitters  at  a  molecular  level.  Increasingly,  therapeutic  goals  are  being  achieved  by  drugs  that  target  selectively  one  or  more  of  the  subtypes  of  5-HT  or  DA  receptors,  or  that  act  on  a  combination  of  both  5-HT  and  DA  receptors.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2022/01/29
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1127865917
ER  -