TY - CHAP M1 - Book, Section TI - Tuberculosis A1 - Doucette, Karen A1 - Cooper, Ryan A2 - Grippi, Michael A. A2 - Elias, Jack A. A2 - Fishman, Jay A. A2 - Kotloff, Robert M. A2 - Pack, Allan I. A2 - Senior, Robert M. A2 - Siegel, Mark D. Y1 - 2015 N1 - T2 - Fishman's Pulmonary Diseases and Disorders, 5e AB - Tuberculosis (TB) is a severe and contagious disease caused by infection with members of the Mycobacteria tuberculosis complex (MTBC). Most often involving the lungs, TB is transmitted by cough, with an infectious dose of less than 10 bacteria.1 Case fatality rates in untreated active pulmonary TB approach nearly 60%.2 Major medical advances of the past half-century have brought effective treatment capable of cure in nearly all identified cases.3,4 Despite this TB causes hundreds of thousands of deaths worldwide every year. The morbidity and mortality burden of TB is not uniformly distributed throughout the globe but rather disproportionately affects those living in poverty and those from resource-limited settings.5 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1122369752 ER -