TY  - CHAP
M1  - Book, Section
TI  - Allergic Bronchopulmonary Aspergillosis (Mycosis) and Severe Asthma with Fungal Sensitivity
A1  - Chupp, Geoffrey L.
A2  - Grippi, Michael A.
A2  - Elias, Jack A.
A2  - Fishman, Jay A.
A2  - Kotloff, Robert M.
A2  - Pack, Allan I.
A2  - Senior, Robert M.
A2  - Siegel, Mark D.
Y1  - 2015
N1  - 
T2  - Fishman's Pulmonary Diseases and Disorders, 5e
AB  - Allergic  bronchopulmonary  aspergillosis  (ABPA)  is  an  idiopathic  inflammatory  disease  of  the  lung,  characterized  by  an  allergic  inflammatory  response  to  colonization  of  the  airways  by  Aspergillus  fumigatus  or  other  fungi.  The  entity  was  first  described  in  1952  by  Hinson  et  al.,  and  then  again  in  1967,  when  Scadding  recognized  an  association  between  the  disease  and  proximal  bronchiectasis  in  areas  previously  affected  by  infiltrates  (predominantly  in  the  upper  lobes).1,2  The  first  adult  case  of  ABPA  was  reported  in  the  United  States  in  1968.3  Although  most  cases  entail  hypersensitivity  to  Aspergillus  spp.  (especially  A.  fumigatus),  the  finding  of  a  virtually  identical  clinical  syndrome  associated  with  immune  sensitivity  to  Candida  albicans  (most  commonly),  Helminthosporium,  Alternaria,  Curvularia  lunata,  Drechslera  hawaiiensis,  Stemphylium  languinosum,  Saccharomyces  cerevisiae,  or  Pseudallescheria  boydii  has  led  some  to  use  the  term  allergic  bronchopulmonary  mycosis  to  describe  the  syndrome.4  However,  since  the  predominant  causative  organism  is  A.  fumigatus  and  the  commercially  available  laboratory  testing  is  for  this  organism,  ABPA  is  primarily  designated  as  the  diagnosis.  In  addition,  a  new  entity  has  been  recently  recognized  that  appears  to  be  on  the  continuum  between  fungal  allergy,  at  one  end,  and  ABPA  at  the  other:  severe  asthma  with  fungal  sensitivity  (SAFS).5  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1122359648
ER  -