TY - CHAP M1 - Book, Section TI - Aspirin- and Exercise-Induced Asthma A1 - Gomez, Jose L. A1 - Chupp, Geoffrey L. A1 - Geba, Gregory P. A2 - Grippi, Michael A. A2 - Elias, Jack A. A2 - Fishman, Jay A. A2 - Kotloff, Robert M. A2 - Pack, Allan I. A2 - Senior, Robert M. A2 - Siegel, Mark D. Y1 - 2015 N1 - T2 - Fishman's Pulmonary Diseases and Disorders, 5e AB - Asthma is well known to be triggered by specific immune factors such as aeroallergen exposures. There are, however, several important nonallergic triggers for the development of asthmatic bronchial obstruction. Two of the most important are aspirin and related nonsteroidal anti-inflammatory drugs (NSAIDS) and exercise. Both can provoke airway responses in the setting of established symptomatic aeroallergen-induced asthma or in isolation. These two nonspecific triggers may also share pathophysiologic mechanisms, including mast cell and leukotriene-related pathways, and may be related to vascular response–mediated airway narrowing. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1122359583 ER -