TY - CHAP M1 - Book, Section TI - Physiologic and Metabolic Study of Pulmonary Disorders Using Conventional Imaging Techniques and Positron Emission Tomography A1 - El-Haddad, Ghassan A1 - Hess, Søren A1 - Worsley, Daniel A1 - Alavi, Abass A2 - Grippi, Michael A. A2 - Elias, Jack A. A2 - Fishman, Jay A. A2 - Kotloff, Robert M. A2 - Pack, Allan I. A2 - Senior, Robert M. A2 - Siegel, Mark D. Y1 - 2015 N1 - T2 - Fishman's Pulmonary Diseases and Disorders, 5e AB - Since the mid-1950s, the use of radiopharmaceuticals has made it possible to assess a variety of pulmonary disorders. In 1955, 133Xe was introduced for the study of regional pulmonary ventilation.1 Shortly thereafter, it became possible to evaluate regional pulmonary blood flow using inhaled carbon dioxide containing radioactive 15O2 or intravenous injection of 133Xe dissolved in saline solution.3 In 1964, intravenous injection of 131I-macroaggregated albumin made it feasible to obtain perfusion scans of the lungs.4 Although these techniques rapidly gained wide acceptance as tests of regional abnormalities in ventilation and pulmonary blood flow, the main practical application has been in the diagnostic evaluation of patients with suspected pulmonary embolism (PE). Increasingly, the role of nuclear medicine in respiratory medicine has been expanded to include disorders such as preoperative assessment of lung function, inflammatory lung disease, and lung cancer. The more widespread availability of positron emission tomography (PET) and integrated PET/CT (computed tomography) has provided powerful tools to aid in the diagnosis, staging, and management of patients with lung cancer. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1122357557 ER -