TY - CHAP M1 - Book, Section TI - The Biochemistry of Aging A1 - Kennelly, Peter J. A2 - Rodwell, Victor W. A2 - Bender, David A. A2 - Botham, Kathleen M. A2 - Kennelly, Peter J. A2 - Weil, P. Anthony Y1 - 2016 N1 - T2 - Harper's Illustrated Biochemistry, 30e AB - OBJECTIVESAfter studying this chapter, you should be able to:Describe the essential features of wear and tear theories of aging.List at least four common environmental factors known to damage biological macromolecules such as proteins and DNA.Describe why nucleotide bases are especially vulnerable to damage.Describe the most physiologically important difference between mitochondrial and nuclear genomes.Describe the oxidative theory of aging and name the primary sources of reactive oxygen species (ROS) in humans.Describe three mechanisms by which cells prevent or repair damage inflicted by ROS.Describe the basic tenets of metabolic theories of aging.Describe the mechanism of the telomere “countdown clock.”Describe our current understanding of the genetic contribution to aging.Explain the evolutionary implications of a genetically encoded lifespan. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2023/02/01 UR - accessmedicine.mhmedical.com/content.aspx?aid=1106061224 ER -