TY  - CHAP
M1  - Book, Section
TI  - The Biochemistry of Aging
A1  - Kennelly, Peter J.
A2  - Rodwell, Victor W.
A2  - Bender, David A.
A2  - Botham, Kathleen M.
A2  - Kennelly, Peter J.
A2  - Weil, P. Anthony
Y1  - 2016
N1  - 
T2  - Harper's Illustrated Biochemistry, 30e
AB  - OBJECTIVESAfter  studying  this  chapter,  you  should  be  able  to:Describe  the  essential  features  of  wear  and  tear  theories  of  aging.List  at  least  four  common  environmental  factors  known  to  damage  biological  macromolecules  such  as  proteins  and  DNA.Describe  why  nucleotide  bases  are  especially  vulnerable  to  damage.Describe  the  most  physiologically  important  difference  between  mitochondrial  and  nuclear  genomes.Describe  the  oxidative  theory  of  aging  and  name  the  primary  sources  of  reactive  oxygen  species  (ROS)  in  humans.Describe  three  mechanisms  by  which  cells  prevent  or  repair  damage  inflicted  by  ROS.Describe  the  basic  tenets  of  metabolic  theories  of  aging.Describe  the  mechanism  of  the  telomere  “countdown  clock.”Describe  our  current  understanding  of  the  genetic  contribution  to  aging.Explain  the  evolutionary  implications  of  a  genetically  encoded  lifespan.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2022/05/25
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1106061224
ER  -