TY - CHAP M1 - Book, Section TI - T Lymphocytes in the Lung A1 - Cohn, Lauren E. A2 - Grippi, Michael A. A2 - Elias, Jack A. A2 - Fishman, Jay A. A2 - Kotloff, Robert M. A2 - Pack, Allan I. A2 - Senior, Robert M. A2 - Siegel, Mark D. Y1 - 2015 N1 - T2 - Fishman's Pulmonary Diseases and Disorders, 5e AB - The lung is a major site of exposure to the outside world in air-breathing species. Lung immunity has developed to recognize pathogens and activate appropriate responses, to temper inflammation in response to nonpathogenic exposures and turn off immune responses when danger signals have been eliminated. T lymphocytes play a major role in lung immunity predominantly through the induction of CD4 and CD8 T cells in adaptive immunity. A number of smaller subsets of T lymphocytes also play critical roles in early immune responses to pathogens and stimulating adaptive immune responses. Long-lived memory CD4 and CD8 T cells are crucial for host protection from pathogens, but also may drive chronic disease states, such as asthma. In this chapter the basic biology of T lymphocytes and their relevance in the lung in health and disease will be reviewed. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1122356229 ER -