TY - CHAP M1 - Book, Section TI - Multiple Endocrine Neoplasia Type 1 A1 - Xekouki, Paraskevi A1 - Gourgari, Evgenia A1 - Stratakis, Constantine A. A2 - Murray, Michael F. A2 - Babyatsky, Mark W. A2 - Giovanni, Monica A. A2 - Alkuraya, Fowzan S. A2 - Stewart, Douglas R. Y1 - 2014 N1 - T2 - Clinical Genomics: Practical Applications in Adult Patient Care AB - Disease summary:The term multiple endocrine neoplasia 1 (MEN1) refers to a familial tumor syndrome characterized by the combination of tumors of the parathyroid glands, pancreatic islet cells, and anterior pituitary gland.Patients may also develop adrenal cortical tumors, carcinoid tumors, facial angiofibromas, collagenomas, and lipomas.Parathyroid tumors are the first manifestation of MEN1 in more than 85% of patients. In less than 15% of patients, the first manifestation may be an insulinoma or prolactinoma.The frequency of MEN1 is estimated to be 1 case in 30,000 persons with a female to male ratio of 1:1.The age of onset of endocrine tumors is usually in the teenaged years; however, the diagnosis is frequently delayed until the fourth decade of life. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1102701416 ER -