TY - CHAP M1 - Book, Section TI - Abdominal Aortic Aneurysm A1 - Kuivaniemi, S. Helena A1 - C. Tromp, Gerard A1 - Hinterseher, Irene A1 - Carey, David J. A2 - Murray, Michael F. A2 - Babyatsky, Mark W. A2 - Giovanni, Monica A. A2 - Alkuraya, Fowzan S. A2 - Stewart, Douglas R. Y1 - 2014 N1 - T2 - Clinical Genomics: Practical Applications in Adult Patient Care AB - Disease summary:Abdominal aortic aneurysms (AAAs), defined as dilatations of the aorta, are a complex disease with both genetic and environmental risk factors.Prevalence: 1% to 2% of Caucasian populations harbor AAAs in industrialized countries. Prevalence increases with age to about 10% among men over 65 years of age.AAA is the 17th leading cause of death in the United States, with approximately 15,000 deaths per year.Risk factors: The most important known risk factors are smoking, positive family history, advanced age, and male sex. Elevated cholesterol levels and hypertension are mild risk factors. Diabetes, African-American ethnicity, and female sex are protective factors.AAAs have a complex, poorly understood pathophysiology, in which inflammation, smooth muscle cell apoptosis, reactive oxygen species, extracellular matrix degradation, and activation of matrix metalloproteinases play a role. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1102699743 ER -