TY - CHAP M1 - Book, Section TI - Dilated Cardiomyopathy A1 - Sager, Solomon A1 - Dolinsky, Jill S. A1 - Hershberger, Ray E. A2 - Murray, Michael F. A2 - Babyatsky, Mark W. A2 - Giovanni, Monica A. A2 - Alkuraya, Fowzan S. A2 - Stewart, Douglas R. Y1 - 2014 N1 - T2 - Clinical Genomics: Practical Applications in Adult Patient Care AB - Disease summary:Dilated cardiomyopathy (DCM) is characterized by left ventricular (LV) enlargement and systolic dysfunction.The prevalence of DCM is 1 in 2700, however, this is undoubtedly an underestimate.Histologic findings include myocyte hypertrophy, myocyte loss, and interstitial fibrosis.Approximately 35% of DCM cases are deemed idiopathic dilated cardiomyopathy (IDC) after detectable causes have been excluded (Fig. 24-1).20% to 50% of IDC may be found in one or more family members, and if so, is termed familial dilated cardiomyopathy (FDC). Of these cases, approximately 20% to 25% have identifiable genetic mutations correlating with disease phenotype. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1102699424 ER -