TY - CHAP M1 - Book, Section TI - Chapter 5. Musculoskeletal Oncology A1 - Randall, R. Lor A1 - Ward, Russell A1 - Hoang, Bang H. A2 - Skinner, Harry B. A2 - McMahon, Patrick J. Y1 - 2014 N1 - T2 - Current Diagnosis & Treatment in Orthopedics, 5e AB - Musculoskeletal oncology is a field of medicine that involves the diagnosis and management of neoplastic conditions affecting the musculoskeletal system. This not only entails neoplasia of mesenchymal origin (derived from embryonic mesoderm), but also metastatic carcinoma and a variety of pseudotumorous conditions. Mesenchymal tumors are an extremely heterogeneous group of neoplasms including over 200 benign conditions and 90 types of sarcoma, and so the majority of this chapter is dedicated to them. The relative incidence of benign to malignant disease is 200:1. These tumors are classified histomorphologically based on features of differentiation, but there is considerable overlap. It is favorable to consider these separate conditions as points on a continuum, rather than entirely distinct entities. Classification, nevertheless, is important because it may yield insight to the behavior, treatment response, and overall prognosis. Benign disease, by definition, behaves in a nonaggressive fashion and exhibits little tendency to locally recur or metastasize. Sarcomas (malignant tumors of mesenchymal origin), however, can be rapidly destructive, have metastatic potential, and have a tendency to locally recur. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=57813481 ER -