TY - CHAP M1 - Book, Section TI - Chapter 35. Polyarteritis Nodosa A1 - Stone, John H. A2 - Imboden, John B. A2 - Hellmann, David B. A2 - Stone, John H. Y1 - 2013 N1 - T2 - CURRENT Diagnosis & Treatment: Rheumatology, 3e AB - Subacute onset of constitutional complaints (eg, fever, weight loss, malaise, arthralgias), lower extremity nodules and ulcerations, mononeuritis multiplex, and intestinal angina (postprandial pain caused by the involvement of mesenteric vessels).Cutaneous polyarteritis nodosa (PAN) is a variant of the systemic disease in which vasculitis is limited to the skin, usually presenting as nodules that break down into ulcers.Angiogram or biopsy of an involved organ required for diagnosis.Angiography may reveal microaneurysms in the kidneys or gastrointestinal tract.Biopsies of the skin and peripheral nerves (with sampling of the adjacent muscle) are the least invasive ways of confirming the diagnosis histopathologically. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/04/19 UR - accessmedicine.mhmedical.com/content.aspx?aid=57273396 ER -