TY - CHAP M1 - Book, Section TI - Chapter 36. Effect of Mechanical Ventilation on Heart–Lung Interactions A1 - Gomez, Hernando A1 - Pinsky, Michael R. A2 - Tobin, Martin J. Y1 - 2013 N1 - T2 - Principles and Practice of Mechanical Ventilation, 3e AB - The heart and lungs are intimately coupled by their anatomical proximity within the thorax and, more importantly, by their responsibility to deliver the O2 requirements of individual cells and organs while excreting the CO2 by-product of metabolism. During critical illness, if these two organ systems fail, either alone or in combination, the end result is an inadequate O2 delivery to the body with inevitable tissue ischemia, progressive organ dysfunction, and if untreated, death. Thus, restoration and maintenance of normalized cardiopulmonary function is an essential and primary goal in the management of critically ill patients. Heart failure can impair gas exchange by inducing pulmonary edema and limiting blood flow to the respiratory muscles. Ventilation can alter cardiovascular function by altering lung volume, and intrathoracic pressure (ITP), and by increasing metabolic demands. These processes are discussed from the perspective of the impact that ventilation has on the cardiovascular system. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=57072018 ER -