TY - CHAP M1 - Book, Section TI - Chapter 61. Perioperative Management of Patients Who Are Receiving Oral Anticoagulant Therapy A1 - Donadini, Marco Paolo A1 - Douketis, James D. A2 - McKean, Sylvia C. A2 - Ross, John J. A2 - Dressler, Daniel D. A2 - Brotman, Daniel J. A2 - Ginsberg, Jeffrey S. Y1 - 2012 N1 - T2 - Principles and Practice of Hospital Medicine AB - The perioperative management of patients who require interruption of a vitamin K antagonist (VKA) because of surgery or another non-invasive procedure is a common and sometimes challenging clinical problem. Bridging anticoagulation refers to the use of a short-acting anticoagulant,which is usually therapeutic-dose subcutaneous low-molecular-weight heparin (LMWH) such as enoxaparin 1 mg/kg twice-daily, administered during the time when a VKA is interrupted and there is no therapeutic anticoagulation. However, there is no standardized definition of ’bridging anticoagulation’ and other treatment regimens, including low-dose (enoxaparin 40 mg once-daily) or intermediate-dose (eg, enoxaparin 40 mg twice-daily) LMWH regimens, have been used, particularly in selected patients at high risk for bleeding complications. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/04/19 UR - accessmedicine.mhmedical.com/content.aspx?aid=56195401 ER -