TY  - CHAP
M1  - Book, Section
TI  - Chapter 217. Topical Retinoids
A1  - Chien, Anna L.
A1  - Voorhees, John J.
A1  - Kang, Sewon
A2  - Goldsmith, Lowell A.
A2  - Katz, Stephen I.
A2  - Gilchrest, Barbara A.
A2  - Paller, Amy S.
A2  - Leffell, David J.
A2  - Wolff, Klaus
Y1  - 2012
N1  - 
T2  - Fitzpatrick's Dermatology in General Medicine, 8e
AB  - |PrintRetinoids  at  a  GlanceDefinition:  any  molecule  that  by  itself  or  through  metabolic  conversion  binds  to  and  activates  retinoic  acid  receptors.Retinoid  receptors:  ligand-dependent  transcription  factors.Predominant  retinoid  receptors  in  human  skin:  retinoic  acid  receptor-g  (RAR-g)  and  retinoid  X  receptor-α  (RXR-α).  RAR-γ/RXR-α  heterodimers  bind  to  retinoic  acid-responsive  elements  and  are  responsible  for  retinoid  signaling.Clinical  use  of  topical  retinoids:  Approved  indications—acne,  psoriasis,  cutaneous  T-cell  lymphoma,  Kaposi  sarcoma,  melasma,  and  photoaged  skin.Unapproved  indications  with  clinical  studies  supporting  benefit—postinflammatory  hyperpigmentations  early  stretch  marks  and  natural  aging.Local  skin  irritation:  mainly  due  to  retinoid-induced  epidermal  hyperplasia.  Clinical  use  should  be  titrated  based  on  the  severity  of  local  reactions.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/24
UR  - accessmedicine.mhmedical.com/content.aspx?aid=56096963
ER  -