TY  - CHAP
M1  - Book, Section
TI  - Chapter 215. Pharmacokinetics and Topical Applications of Drugs
A1  - Schaefer, Hans
A1  - Redelmeier, Thomas E.
A1  - Nohynek, Gerhard J.
A1  - Lademann, Jürgen
A2  - Goldsmith, Lowell A.
A2  - Katz, Stephen I.
A2  - Gilchrest, Barbara A.
A2  - Paller, Amy S.
A2  - Leffell, David J.
A2  - Wolff, Klaus
Y1  - 2012
N1  - 
T2  - Fitzpatrick's Dermatology in General Medicine, 8e
AB  - |PrintPharmacokinetics  at  a  GlanceCompounds  applied  topically  to  the  skin  surface  migrate  along  concentration  gradients.The  drug  or  its  formulation  may  affect  the  skin  barrier,  resulting  in  time-dependent  changes  of  the  barrier  function.There  are  significant  regional  variations  in  the  barrier  properties  of  the  skin.Formulations  differ  in  their  physicochemical  properties—this  influences  the  kinetics  of  release  and/or  absorption  and  the  onset,  duration,  and  extent  of  a  biologic  response.The  primary  compartment  that  limits  the  percutaneous  absorption  of  compounds  is  the  stratum  corneum.Diffusion  within  the  viable  tissue,  as  well  as  metabolism  and  resorption,  also  influence  the  bioavailability  of  compounds  in  specific  skin  compartments.Metabolic  activity  is  a  primary  consideration  in  the  design  of  prodrugs  and  may  influence  the  bioavailability  of  drugs  delivered  via  dermatologic  or  transdermal  formulations.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/25
UR  - accessmedicine.mhmedical.com/content.aspx?aid=56096553
ER  -