TY - CHAP M1 - Book, Section TI - Chapter 214. Principles of Topical Therapy A1 - Souza, Aieska De A1 - Strober, Bruce E. A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus Y1 - 2012 N1 - T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintPrinciples of Topical Therapy at a GlanceThe efficacy of a topically applied drug depends on its inherent potency and on its ability to penetrate skin.Some factors that affect penetration include: concentration of medication, thickness and integrity of the stratum corneum, frequency of application, occlusiveness of the vehicle, and compliance.Topical formulations (vehicles) are meant to enhance the beneficial effects of the medication.Either the vehicle or its active ingredient(s) may cause local toxicity.Topical medications may induce systemic toxicity. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=56096360 ER -