TY - CHAP M1 - Book, Section TI - Chapter 197. Human T-Lymphotropic Viruses A1 - Tschachler, Erwin A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus Y1 - 2012 N1 - T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintHuman T-Lymphotropic Virus 1-Induced Skin Diseases at a GlanceAn estimated 10–20 million people are infected by human T-cell lymphotropic virus type 1 (HTLV-1) worldwide, with endemic pockets of high prevalence in Southern Japan and the Caribbean islands.Infective dermatitis is a recalcitrant form of eczema occurring in HTLV-1-infected children in the Caribbean.Adult T-cell leukemia (ATL) shows monoclonal HTLV-1 provirus integration in tumor cells and occurs in four clinical variants, all of which tend to show skin involvement:Smoldering ATL—5% of all cases.Chronic ATL—15% of all cases.Lymphoma-type ATL—20% of all cases.Acute ATL—60% of all cases.The prognosis of lymphoma-type and acute ATL is very poor despite chemotherapy, with a projected 4-year survival of 5%. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/04/18 UR - accessmedicine.mhmedical.com/content.aspx?aid=56089694 ER -