TY - CHAP M1 - Book, Section TI - Chapter 164. Systemic Necrotizing Arteritis A1 - Merkel, Peter A. A1 - Monach, Paul A. A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus Y1 - 2012 N1 - T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintSystemic Vasculitis at a GlanceHeterogenous group of rare inflammatory conditions in which blood vessel walls are primarily targeted by an inflammatory reaction.Etiology unknown; geographic, environmental, and genetic factors may be important.Incidence up to 42 cases per million per year.Diagnosis often established in patients with multiple but variable organ involvement; supported by laboratory or radiologic studies and histologic evidence of inflammatory reaction in blood vessels.Cutaneous involvement can occur in any of the primary systemic vasculitic syndromes.Cutaneous features are often not sufficient to provide complete diagnosis and staging.Classification of the vasculitides is based on several factors including known etiology or disease association (primary vs. secondary forms), predominant size of involved vessels (small, medium, or large arteries), and additional clinical and laboratory data.Primary vasculitis is a diagnosis of exclusion after causes of secondary vascular inflammation have been ruled out.Determinants of prognosis and treatment include the specific vasculitic syndrome, whether critical organs are involved, the severity of involvement, and the rate of disease progression.Treatment often requires glucocorticoids and the use of other immunosuppressive drugs. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=56078520 ER -