TY - CHAP M1 - Book, Section TI - Chapter 148. Non-Langerhans Cell Histiocytosis A1 - Gelmetti, Carlo A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus Y1 - 2012 N1 - T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintNonlangerhans Cell Histiocytosis at a GlanceA broad group of disorders characterized by the proliferation of histiocytes involving cells other than Langerhans cells.Not rare. Most cases are in infants and run a benign, self-healing course lasting a few years.The primary histopathologic feature is a dense, diffuse infiltrate that is less epidermotropic than in Langerhans cell histiocytosis (LCH) and composed of occasionally foamy macrophages intermingled with lymphocytes, plasma cells, eosinophils, and sometimes Touton giant cells.In typical cases, histiocytes are CD68+ but CD1a– and CD207–.Most common sites of involvement are the head, trunk, and skin folds, with mucosal lesions rare.Systemic manifestations such as ocular involvement, diabetes insipidus, and joint and visceral impairment are rare in juvenile xanthogranuloma, the most common type of non-Langerhans cell histiocytosis (NLCH), but are common in the rarer forms of NLCH. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=56072946 ER -