TY - CHAP M1 - Book, Section TI - Chapter 133. Amyloidosis of the Skin A1 - Lachmann, Helen J. A1 - Hawkins, Philip N. A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus Y1 - 2012 N1 - T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintAmyloidosis and the Skin at a GlanceIn amyloidosis normally soluble plasma proteins are deposited in the extracellular space in an abnormal insoluble fibrillar form.Amyloid deposition is remarkably diverse and can be localized or systemic, rapidly lethal or incidental.Diagnosis of amyloidosis relies on the demonstration of pathognomonic red–green birefringence when biopsies stained with Congo red are viewed under cross-polarized light.Management relies on determining the type (defined by the precursor protein) and discriminating systemic from localized forms.Treatment of systemic disease centers on reducing the production of the fibril precursor protein and management of localized disease is usually surgical or symptomatic. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=56066820 ER -