TY - CHAP M1 - Book, Section TI - Chapter 73. Albinism and Other Genetic Disorders of Pigmentation A1 - Hornyak, Thomas J. A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus Y1 - 2012 N1 - T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintAlbinism and Congenital Disorders of Pigmentation at a GlanceWorldwide occurrenceAlbinism is usually inherited as a recessive trait, but other congenital disorders of pigmentation are usually inherited as dominant traits. There can be marked differences in penetrance.Clinical features of albinism may include lightly pigmented or nonpigmented skin and silvery-white or light hair color.Ocular nystagmus and reduced visual acuity are important features of albinism that distinguish albinism from other congenital disorders of pigmentation.Clinical features of congenital disorders of pigmentation include patches of white hair (poliosis), variations in iris color, and depigmented patches of white skin.The presence of ocular nystagmus is useful for distinguishing albinism from congenital disorders of pigmentation.Albino skin contains melanocytes with reduced or absent DOPA-positivity. Depigmented patches in congenital disorders of pigmentation lack melanocytes. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=56042949 ER -