TY  - CHAP
M1  - Book, Section
TI  - Chapter 65. Lichen Sclerosus
A1  - Hengge, Ulrich R.
A2  - Goldsmith, Lowell A.
A2  - Katz, Stephen I.
A2  - Gilchrest, Barbara A.
A2  - Paller, Amy S.
A2  - Leffell, David J.
A2  - Wolff, Klaus
Y1  - 2012
N1  - 
T2  - Fitzpatrick's Dermatology in General Medicine, 8e
AB  - |PrintLichen  Sclerosus  at  a  GlanceInfrequent  chronic  inflammatory  dermatosis  with  anogenital  and  extragenital  manifestations.Preferentially  affects  women  in  the  fifth  or  sixth  decade  of  life  and  children  younger  than  the  age  of  10  years;  gender  ratio  5:1  female–male.Antibodies  to  extracellular  matrix  protein-1  and  T  cells  with  receptor  rearrangement  point  to  an  autoimmune  pathogenesis.Anogenital  manifestations  cause  severe  discomfort  (pruritus,  dyspareunia,  dysuria,  and  painful  defecation)  and  present  with  polygonal  papules  and  porcelain-white  plaques,  erosions,  and  various  degrees  of  sclerosis.Vulvar  lichen  sclerosus  is  associated  with  an  increased  risk  of  squamous  cell  carcinoma;  the  role  of  human  papillomavirus  infection  or  prior  radiotherapy  remains  to  be  elucidated.Potent  topical  corticosteroids  and  skin  care  are  the  most  successful  therapeutics;  calcineurin  antagonists  have  also  recently  demonstrated  benefit.Interdisciplinary  management  is  essential  for  long-term  control.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/18
UR  - accessmedicine.mhmedical.com/content.aspx?aid=56040547
ER  -