TY - CHAP M1 - Book, Section TI - Chapter 58. Linear Immunoglobulin A Dermatosis and Chronic Bullous Disease of Childhood A1 - Rao, Caroline L. A1 - Hall, Russell P. A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus Y1 - 2012 N1 - T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintLinear Immunoglobulin A Dermatosis at a GlanceRare blistering disease with onset typically after fourth decade of life.Linear band of immunoglobulin A at the dermal–epidermal basement membrane.Clinical presentations may mimic dermatitis herpetiformis, bullous pemphigoid, and cicatricial pemphigoid.May occur in association with many drugs, including vancomycin.May occur in association with inflammatory bowel diseases but only rarely associated with gluten sensitive enteropathy.Rarely seen in association with malignancy, specifically lymphoid.Histology shows subepidermal collection of neutrophils at the basement membrane, often collecting in papillary tips with subepidermal blisters.Most patients respond dramatically to treatment with dapsone; some require adjunctive systemic corticosteroids.Prognosis variable with both spontaneous remissions and long-standing disease. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/11/07 UR - accessmedicine.mhmedical.com/content.aspx?aid=56038321 ER -