TY  - CHAP
M1  - Book, Section
TI  - Chapter 56. Bullous Pemphigoid
A1  - Culton, Donna A.
A1  - Liu, Zhi
A1  - Diaz, Luis A.
A2  - Goldsmith, Lowell A.
A2  - Katz, Stephen I.
A2  - Gilchrest, Barbara A.
A2  - Paller, Amy S.
A2  - Leffell, David J.
A2  - Wolff, Klaus
Y1  - 2012
N1  - 
T2  - Fitzpatrick's Dermatology in General Medicine, 8e
AB  - |PrintBullous  Pemphigoid  at  a  GlanceUsually  occurs  in  elderly  patients.Yearly  mortality  varies  from  6%  to  40%.Pruritic  urticarial  lesions  and  tense  large  blisters.  Oral  mucous  membrane  erosions  in  minority  of  patients.Skin  pathology  shows  subepidermal  blisters  with  eosinophils.Direct  immunofluorescence  shows  immunoglobulin  (Ig)  G  and  C3  at  epidermal  basement  membrane  of  perilesional  skin,  indirect  immunofluorescence  shows  IgG  antibasement  membrane  autoantibodies  in  the  serum.The  autoantigens  BPAg1e  and  the  BP180  are  proteins  of  the  keratinocyte  hemidesmosome,  a  basal  cell–basement  membrane  adhesion  structure.Therapy  includes  topical  and  systemic  corticosteroids  and  immunosuppressives.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/20
UR  - accessmedicine.mhmedical.com/content.aspx?aid=56037796
ER  -