TY - CHAP M1 - Book, Section TI - Chapter 50. Inherited Palmoplantar Keratodermas A1 - Zamiri, Mozheh A1 - van Steensel, Maurice A. M. A1 - Munro, Colin S. A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus Y1 - 2012 N1 - T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintInherited Palmoplantar Keratodermas at a Glance1–8Palmoplantar keratoderma (PPK) is chronic and pathological thickening, predominantly due to hyperkeratosis, of the hairless skin of palms and soles.PPK may be acquired in inflammatory skin diseases such as eczema, psoriasis, and lichen planus, and has been reported as a paraneoplastic phenomenon.Genetically determined PPKs are a heterogeneous group of individually rare disorders inherited by a variety of mechanisms or occurring sporadically.PPK may form part of ectodermal syndromes or be associated with other systemic anomalies. Important associations of specific PPKs include cardiomyopathy, impaired hearing, neuropathy and neurodevelopmental defects, and esophageal cancer.The mechanisms of inherited PPK include altered differentiation arising from defects in synthesis, distribution or function of structural components such as intermediate filaments, desmosomes and gap junction proteins, or altered inflammatory responses.The severity of palmoplantar hyperkeratosis varies from inconvenience to major functional and social disability. Plantar pain in focal keratoderma is one of the most debilitating features, with hyperhidrosis and secondary dermatophyte infection contributing to symptoms.Treatment is unsatisfactory, as it relies largely on physical treatments and appropriate foot care, but oral retinoids are of value in some cases. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=56035898 ER -