TY  - CHAP
M1  - Book, Section
TI  - Chapter 33. Pyoderma Gangrenosum
A1  - Powell, Frank C.
A1  - Hackett, Bridget C.
A1  - Wallach, Daniel
A2  - Goldsmith, Lowell A.
A2  - Katz, Stephen I.
A2  - Gilchrest, Barbara A.
A2  - Paller, Amy S.
A2  - Leffell, David J.
A2  - Wolff, Klaus
Y1  - 2012
N1  - 
T2  - Fitzpatrick's Dermatology in General Medicine, 8e
AB  - |PrintPyoderma  Gangrenosum  at  a  GlancePyoderma  gangrenosum  (PG)  is  a  rare  inflammatory  disease  of  unknown  etiology  characterized  by  sterile  neutrophilic  infiltration  of  the  skin.  Similar  neutrophilic  infiltrations  may  occur  in  other  organs.  It  is  considered  to  be  one  of  the  groups  of  neutrophilic  dermatoses  and  clinical  and  histological  overlap  with  some  of  these  may  occur.PG  is  more  frequent  in  female  patients  and  occurs  at  any  age,  but  usually  between  40  and  60  years.The  majority  of  patients  with  PG  have  other  systemic  diseases  (such  as  arthritis,  inflammatory  bowel  disease,  hematological  dyscrasias,  malignant  disease,  etc.),  but  PG  occurs  independently  of  these  disorders.PG  may  present  as  ulcerative,  bullous,  pustular,  or  vegetative  variants.  Clinical  features  of  different  variants  sometimes  overlap  in  individual  patients  but  usually  one  variant  dominates  the  clinical  picture.There  is  no  laboratory  test  or  investigation  that  establishes  the  diagnosis  of  PG  with  certainty.  The  histopathological  findings  are  not  diagnostic  but  can  be  supportive  of  the  diagnosis  of  PG  in  the  appropriate  clinical  setting  and  are  essential  to  rule  out  alternative  diagnoses.Specified  criteria  (see  below)  suggest  the  diagnosis  of  PG,  but  other  conditions  (particularly  infection,  vascular  disease,  and  malignancy)  must  be  excluded.The  mainstays  of  management  are  systemic  immunosuppressive  agents  together  with  appropriate  local  and  topical  therapy.Ulcerative  PG  is  a  chronic  disease.  Remission  usually  requires  months  of  treatment;  maintenance  therapy  is  necessary  in  many  and  relapses  are  common.  Significant  morbidity  and  mortality  are  experienced  by  patients  with  ulcerative  and  bullous  PG.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessmedicine.mhmedical.com/content.aspx?aid=56031301
ER  -