TY - CHAP M1 - Book, Section TI - Chapter 23. Exfoliative Dermatitis A1 - Grant-Kels, Jane Margaret A1 - Fedeles, Flavia A1 - Rothe, Marti J. A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus Y1 - 2012 N1 - T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintExfoliative Dermatitis at a GlanceExfoliative dermatitis (ED) is defined as diffuse erythema and scaling of the skin involving more than 90% of the total body skin surface area.Systemic and potentially life-threatening complications include fluid and electrolyte imbalance, thermoregulatory disturbance, fever, tachycardia, high-output failure, hypoalbuminemia, and septicemia.Common underlying etiologies are psoriasis, atopic dermatitis, and other spongiotic dermatoses, drug hypersensitivity reactions, and cutaneous T-cell lymphoma (CTCL). The cause of ED is unknown (idiopathic) in approximately 20% of cases.Diagnostic workup includes a complete history and physical examination, with careful analysis of pertinent clinical clues and dermatohistopathology. Other laboratory workup is often required and determined by clinical clues.Management of ED involves combining symptomatic relief with addressing the underlying etiology and potential systemic complications. Inpatient hospitalization is required in acute cases.Prognosis is variable and depends primarily on the underlying etiology. Drug-induced ED has the best prognosis while malignancy-associated ED has the highest mortality. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/04/23 UR - accessmedicine.mhmedical.com/content.aspx?aid=56027262 ER -