TY - CHAP M1 - Book, Section TI - Chapter 12. Chemokines A1 - Lonsdorf, Anke S. A1 - Hwang, Sam T. A2 - Goldsmith, Lowell A. A2 - Katz, Stephen I. A2 - Gilchrest, Barbara A. A2 - Paller, Amy S. A2 - Leffell, David J. A2 - Wolff, Klaus Y1 - 2012 N1 - T2 - Fitzpatrick's Dermatology in General Medicine, 8e AB - |PrintChemokines at a GlanceChemokines and their receptors are vital mediators of cellular trafficking.Most chemokines are small proteins with molecular weights in the 8- to 10-kDa range.Chemokines are synthesized constitutively in some cells and can be induced in many cell types.Chemokines play roles in inflammation, angiogenesis, neural development, cancer metastasis, hematopoiesis, and infectious disease.In skin, chemokines play important roles in atopic dermatitis, psoriasis, melanoma, melanoma metastasis, and some viral (including retroviral) infections.Promising therapeutic applications of chemokines include the prevention of T-cell arrest on activated endothelium or blocking infection of T cells by human immunodeficiency virus 1 using CC chemokine receptor 5 analogs. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=56023467 ER -