TY - CHAP M1 - Book, Section TI - Chapter 20. Intestinal Malabsorption A1 - Trier, Jerry S. A2 - Greenberger, Norton J. A2 - Blumberg, Richard S. A2 - Burakoff, Robert Y1 - 2012 N1 - T2 - CURRENT Diagnosis & Treatment: Gastroenterology, Hepatology, & Endoscopy, 2e AB - Celiac disease—characteristic though not specific small bowel mucosal lesion, positive anti–tissue transglutaminase test (anti-tTGA) or antiendomysial antibody test (anti-EMA), and clinical response to gluten withdrawal.Tropical sprue—appropriate geographic exposure; exclude other mucosal diseases (eg, celiac disease and protozoal infections), exclude small intestinal bacterial overgrowth, and assess response to antibiotics and folate.Eosinophilic gastroenteritis—histologic demonstration of increased gastric, intestinal, or colonic mucosal or mural eosinophilic infiltration or eosinophilic ascites.Systemic mastocytosis—demonstration of increased mucosal mast cells (>20 per high-power field) in stomach, small bowel, colon; elevated serum tryptase.Radiation enteritis—history of radiation with mucosal telangiectasias, obliterative endarteriolitis, fibrosis, and strictures; small intestinal bacterial overgrowth may develop.Whipple disease—demonstrate Tropheryma whipplei and characteristic periodic acid–Schiff-positive macrophages in intestinal mucosa or other tissue.Small intestinal bacterial overgrowth—document evidence of malabsorption, positive breath test (lactulose, glucose), response to antibiotics.Short bowel syndrome—history of small bowel resection and confirmation by imaging (barium contrast small bowel series or computed tomographic enterography).Intestinal lymphangiectasia—hypoproteinemia, lymphopenia, evidence of protein-losing enteropathy, increased fecal loss of α1-antitrypsin. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=55957611 ER -