TY - CHAP M1 - Book, Section TI - Rheumatoid Arthritis A1 - Manno, Rebecca L. A1 - Yazdany, Jinoos A1 - Tarrant, Teresa K. A1 - Kwan, Mildred A2 - Papadakis, Maxine A. A2 - Rabow, Michael W. A2 - McQuaid, Kenneth R. A2 - Gandhi, Monica Y1 - 2025 N1 - T2 - Current Medical Diagnosis & Treatment 2025 AB - ESSENTIALS OF DIAGNOSISUsually insidious onset with morning stiffness and joint pain.Symmetric polyarthritis with predilection for small joints of the hands and feet; deformities common with progressive disease.Radiographic findings: juxta-articular osteoporosis, joint erosions, and joint space narrowing.Rheumatoid factor and antibodies to cyclic citrullinated peptides (anti-CCP) are present in 70–80%.Extra-articular disease: subcutaneous nodules, interstitial lung disease, pleural effusion, pericarditis, splenomegaly, scleritis, and vasculitis. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2025/07/17 UR - accessmedicine.mhmedical.com/content.aspx?aid=1209233327 ER -