TY  - CHAP
M1  - Book, Section
TI  - Acute Kidney Injury
A1  - Honkanen, Iiro
A1  - Teixeira, J. Pedro
A1  - Griffin, Benjamin R.
A2  - Schmidt, Gregory A.
A2  - Kress, John P.
A2  - Douglas, Ivor S.
Y1  - 2023
N1  - 
T2  - Hall, Schmidt and Wood’s Principles of Critical Care, 5<sup>th</sup> Edition
AB  - KEY  POINTSAcute  Kidney  Injury  (AKI)  is  a  common  medical  condition  that  affects  over  50%  of  ICU  patients,  and  AKI  requiring  RRT  has  a  mortality  rate  higher  than  MI,  sepsis  without  AKI,  or  ARDS  requiring  mechanical  ventilation  in  critically  ill  patients.AKI  does  not  occur  in  isolation,  but  instead  has  systemic  effects  on  distant  organs  including  the  lung,  heart,  liver,  brain,  and  immune  system.Sepsis-associated  AKI  is  the  most  common  cause  of  AKI  in  the  ICU.  Other  causes  include  cardiorenal  syndrome,  cardiac  surgery–associated  AKI,  hepatorenal  syndrome,  acute  liver  failure,  intra-abdominal  hypertension,  and  contrast-associated  AKI.Once  AKI  has  occurred  the  management  is  supportive,  including  with  RRT.  Identifying  patients  at  risk  for  developing  AKI  is  therefore  paramount  for  early  implementation  of  preventive  or  therapeutic  measures.Novel  biomarkers  and  functional  tests  are  useful  for  diagnosing  and  prognosticating  AKI.  The  former  includes  TIMP-2  and  IGFBP7  and  the  latter  includes  the  furosemide  stress  test  (FST).  
SN  - 
PB  - McGraw Hill
CY  - New York, NY
Y2  - 2024/09/11
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1201808800
ER  -