TY - CHAP M1 - Book, Section TI - Pulmonary Mechanics A1 - Pack, Allan I. A1 - Grippi, Michael A. A2 - Grippi, Michael A. A2 - Antin-Ozerkis, Danielle E. A2 - Dela Cruz, Charles S. A2 - Kotloff, Robert M. A2 - Kotton, Camille Nelson A2 - Pack, Allan I. Y1 - 2023 N1 - T2 - Fishman’s Pulmonary Diseases and Disorders, 6e AB - “Arterialization” of venous blood requires matching of the distribution of air and blood within the lung, thereby ensuring effective gas exchange across the alveolar–capillary membrane*. Arterialization comprises a series of interrelated processes that begin with the mechanical performance of the ventilatory apparatus—that is, the lungs and the chest wall, including the rib cage, diaphragm, and abdominal wall. Ventilation is critical for replenishing fresh air to the lungs for gas exchange. Although the function of each component of the lung and of the chest bellows can be deranged by injury or disease, the design of the ventilatory apparatus provides for considerable reserve. As a result, mechanical derangements are usually quite severe by the time clinical symptoms appear or arterial blood-gas levels become abnormal. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1194945972 ER -