TY  - CHAP
M1  - Book, Section
TI  - Intrahepatic Cholestasis of Pregnancy
A1  - Rogers, Vanessa L.
A1  - Roberts, Scott W.
A2  - Papadakis, Maxine A.
A2  - McPhee, Stephen J.
A2  - Rabow, Michael W.
A2  - McQuaid, Kenneth R.
Y1  - 2023
N1  - 
T2  - Current Medical Diagnosis & Treatment 2023
AB  - Intrahepatic  cholestasis  of  pregnancy  is  characterized  by  incomplete  clearance  of  bile  acids  in  genetically  susceptible  women.  The  principal  symptom  is  pruritus,  which  can  be  generalized  but  tends  to  have  a  predilection  for  the  palms  and  soles.  Presentation  is  typically  in  the  third  trimester,  and  women  with  multifetal  pregnancies  are  at  increased  risk.  The  finding  of  an  elevated  serum  bile  acid  level,  ideally  performed  in  the  fasting  state,  confirms  the  diagnosis.  Associated  laboratory  derangements  include  modest  elevations  in  hepatic  transaminase  levels  and  mild  hyperbilirubinemia.  Although  rare,  the  bilirubin  level  may  be  sufficiently  elevated  to  result  in  clinical  jaundice.  The  symptoms  and  laboratory  abnormalities  resolve  quickly  after  delivery  but  can  recur  in  subsequent  pregnancies  or  with  exposure  to  combination  oral  contraceptives.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/20
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1193159563
ER  -