TY  - CHAP
M1  - Book, Section
TI  - Other Causes of Bleeding
A1  - Leavitt, Andrew D.
A1  - Price, Erika Leemann
A2  - Papadakis, Maxine A.
A2  - McPhee, Stephen J.
A2  - Rabow, Michael W.
A2  - McQuaid, Kenneth R.
Y1  - 2023
N1  - 
T2  - Current Medical Diagnosis & Treatment 2023
AB  - Occasionally,  abnormalities  of  the  vasculature  and  integument  may  lead  to  bleeding  despite  normal  hemostasis;  congenital  or  acquired  disorders  may  be  causative.  Congenital  abnormalities  include  Ehlers-Danlos  syndrome,  osteogenesis  imperfecta,  hereditary  hemorrhagic  telangiectasia  (Osler-Weber-Rendu  disease)  (see  Chapter  40),  and  Marfan  syndrome.  Acquired  disorders  include  integument  thinning  due  to  prolonged  corticosteroid  administration  or  normal  aging,  amyloidosis,  vasculitis,  and  scurvy  (acquired  defects).  The  bleeding  time  often  is  prolonged.  The  bleeding  time  reflects  the  integrity  of  the  vasculature  (which  is  abnormal  in  collagen  synthesis  disorders)  in  addition  to  activity  of  platelets  and  coagulation  factors.  If  possible,  treatment  of  the  underlying  condition  should  be  pursued,  but  if  this  is  not  possible  or  feasible  (ie,  congenital  syndromes),  globally  hemostatic  agents  such  as  antifibrinolytic  agents  or  DDAVP  can  be  considered  for  treatment  of  bleeding.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1193158953
ER  -